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The Little Sequatchie River is a major tributary of the Sequatchie River. Unlike its larger namesake, it does not have a spectacular large spring source but is the result of the confluence of many smaller streams in a very remote, scenic area of the Cumberland Plateau along the line between Grundy County and Marion County, Tennessee. It flows down a narrow valley, basically south. Its mouth is near the community of Sequatchie (also rendered "Sequachee").